A Randomized Phase 2 Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy with and without BMX-001 as part of Total Neoadjuvant Therapy in Patients with Newly Diagnosed Locally Advanced Rectal Adenocarcinoma
Categories (click each to see list of all clinical trials associated with that category): GI (ONC)
Current Status: Open
Phase: II (Cancer Control)
Principal Investigator: Lin, Chi
Eligibility: https://www.clinicaltrials.gov/study/NCT05254327?term=NCT05254327&rank=1
Summary
Primary Objective
1. To examine the efficacy of BMX-001 as a normal tissue radioprotector on reduction of acute toxicity of SCRT or LCCRT as part of Total Neoadjuvant Therapy (TNT) (TNT=SCRT or LCCRT plus 5 14-day cycles of FOLFOX prior and 4 14-day cycles of FOLFOX after OR 3 21-day cycles of CAPOX prior and 3 21-day cycles of CAPOX after) followed by cancer surgery for newly diagnosed locally advanced rectal cancer patients.