Clinical Trial Details

Study Using Prebiotics to Improve Gut Microbiome Diversity After Autologous Stem Cell Transplantation PRIMAL Trial

Categories (click each to see list of all clinical trials associated with that category): Lymphoma/CLL (ONC)

Current Status: Open

Phase: Pilot (Cancer Control)

Principal Investigator: D'Angelo, Christopher

Contact Information:
Emily Gale
emily.gale@unmc.edu

Eligibility: https://clinicaltrials.gov/study/NCT05135351?term=NCT05135351&rank=1

Summary
Primary: 1.) To explore the impact of a prebiotic intervention on gut microbiome diversity post-transplant 2.) To understand the feasibility of the intervention in the proposed study population Secondary: 1.) To estimate the rate of neutropenic fever in the post-transplant setting according to intervention assignment 2.) To determine the rate of broad-spectrum antibiotic exposure during transplant according to intervention assignment 3.) To determine the rate of gastrointestinal symptoms according to intervention assignment 4.) To investigate the change to gut microbiota according to pre-transplant dietary intake 5.) To evaluate the duration of hospitalization according to intervention assignment 6.) To evaluate the impact of dose intensity of resistant starch on gut microbiota composition