Clinical Trial Details

Low Dose Radiation as Bridging Therapy for Lisocabtagene Maraleucel in Relapsed B-Cell Non-Hodgkin Lymphoma

Categories (click each to see list of all clinical trials associated with that category): Cellular Therapy Support Service - CAR-T (ONC), Lymphoma/CLL (ONC)

Current Status: Open

Phase: Pilot (Cancer Control)

Principal Investigator: D'Angelo, Christopher

Contact Information:
Sarah Snook


Primary Objective: To understand the feasibility of the intervention in the proposed study population Secondary Objectives: To understand the safety of the proposed intervention To evaluate the response to the study intervention of radiation and CAR-T cell therapy To evaluate progression-free survival (PFS) following the study intervention To evaluate duration of response (DOR) following CAR T-cell therapy To evaluate overall survival (OS) following study intervention To evaluate the rate of prolonged cytopenias following the intervention Correlative/Exploratory Objectives: To bank peripheral blood mononuclear cells (PBMCs) and serum for future correlative research To bank stool samples for future correlative gut microbiome research To evaluate the effect of radiation therapy on local control of disease sites