Benign Blood Disorders

Blood disorders caused by non-malignant (non-cancerous) conditions affecting clotting, bleeding, Red blood cells (RBC), white blood cells (WBC) or platelets are called as benign hematological disorders. They could be conditions present at birth (congenital) due to inherited problems, or acquired due to various things like medications or infections.

Not all benign hematological disorders are alike nor need treatments but appropriate diagnosis and timely treatments are the key to avoid complications. There are many life threatening benign hematological disorders like PNH or TTP etc., which needs immediate treatment, and there are many chronic disorders like anemia, which may need long-term watchful waiting. 

Why Come to Nebraska Medicine

Our team of expert hematologist have deep understanding in benign hematological disorders. We follow a team approach and work closely with not only laboratory and pathology teams but also other specialists including surgeons to offer the best treatment possible.

Along with pediatric hematology/oncology and adult hematology/oncology the team is home to the Nebraska Regional Hemophilia Treatment Center which treats adult and pediatric patients from across the state with bleeding disorders. In addition, we're part of the Heartland Sickle Cell Disease Network, meaning we collaborate with eight other universities to improve sickle cell disease treatments.


We treat

Bleeding disorders

  • Congenital bleeding disorders
  • Hemophilia A and Hemophilia B
  • Von Willebrand disease
  • Acquired bleeding disorders
  • Rare bleeding disorders
  • Coagulation factor deficiencies
  • Management of bleeding disorders around surgery
  • Platelet disorders
  • Deficiency of various clotting factors
  • Other bleeding or bruising disorders
  • Abnormalities with PT/INR and PTT

Thrombotic (Clotting) disorders

  • Deep venous thrombosis (DVT) or venous thromboembolism including portal vein, dural vein, and sinus thrombosis
  • Arterial thromboembolism (VTE)
  • Splanchnic vein thrombosis
  • Portal vein thrombosis
  • Factor V Leiden mutation
  • Prothrombin gene mutation
  • Protein C deficiency
  • Protein S deficiency
  • Antithrombin deficiency. 
  • Family history of thrombophilia (repeated issues with blood clots) or stroke
  • Antiphospholipid antibody syndrome (APS)
  • Positive Lupus anticoagulant
  • Positive antiphospholipid antibodies
  • Anticoagulation management
  • History of miscarriages
  • Heparin-induced thrombocytopenia (HIT)
  • Methylene-tetrahydrofolate reductase (MTHFR)
    • Elevated PTT
    • Protein C/S abnormality
    • Prothrombin Gene Mutation

Low blood counts

  • Idiopathic thrombocytopenia purpura (ITP), an immune-mediated disease causing a low platelet count
  • Other causes of Thrombocytopenia
  • Leucopenia/neutropenia/lymphopenia  
  • Anemia (when the blood does not have enough hemoglobin, which transports oxygen) due to chronic disease. This includes megaloblastic, iron deficiency, inflammatory anemia, hemolytic including autoimmune hemolytic anemia, an immune-mediated disease causing a low red blood cell count
  • Thalassemia, sickle cell anemia or other genetic blood disorders
  • Thrombocytopenia: Low platelet count

High blood counts

  • Elevated white blood count such as leukocytosis, neutrophilia, Eosinophilia orlymphocytosis
  • Secondary Polycythemia (high hemoglobin)
  • Thrombocytosis or high platelets
  • Splenomegaly or Lymphadenopathy
  • Monoclonal Gammopathy of Undetermined Significance ("MGUS")/abnormal serum protein electrophoresis, and other related issues of plasma cells causing unusual proteins in the blood.

Other benign blood disorders

  • Elevated iron levels or hemochromatosis
  • Giant platelets
  • Macrocytosis or microcytosis

Complex bleeding disorders

  • Disseminated intravascular coagulation (DIC)
  • Thrombotic thrombocytopenic purpura or hemolytic uremic syndrome (TTP/aHUS/HUS)
  • Antiphospholipid syndrome
  • Aplastic anemia
  • Budd-Chiari syndrome
  • Congenital dysfibrinogenemia
  • Pregnancy-related bleeding problems
  • Unexplained bleeding

Other complex blood disorders

  • Bone marrow failure and related syndromes
  • Hemoglobinopathy/ Sickle Cell anemia/ Thalassemia
  • Porphyria
  • Sideroblastic anemia
  • Hemophagocytosis