cancer clinical trials for FPBCC CTO Studies

101 FPBCC CTO Studies clinical trials found. View a list of all cancer clinical trial types.

• A Randomized Phase III Trial of Carboplatin, Paclitaxel, Pembrolizumab Versus Carboplatin, Paclitaxel, Bevacizumab Versus Carboplatin, Paclitaxel, Pembrolizumab, Bevacizumab in the Treatment of pMMR, TP53 Mutated Advanced or Recurrent Endometrial Cancer

  Current Status: Open

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• A Phase III, Randomized, Open-label, Multicenter Study of Sacituzumab Tirumotecan (sac-TMT, MK-2870) Maintenance Treatment With or Without Bevacizumab Versus Standard of Care in Participants With Newly Diagnosed Advanced non-HRD positive Ovarian Cancer Following First-line Platinum- based Chemotherapy (TroFuse-021/ENGOTov85/GOG-3102)

  Current Status: Open

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• A Phase III Randomized, Open-label Study of Rinatabart Sesutecan (Rina-S) Versus Treatment of Investigator's Choice (IC) in Patients With Platinum Resistant Ovarian Cancer

  Current Status: Open

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• A Phase III Trial of One vs. Two Years of Maintenance Olaparib, With or Without Bevacizumab, in Patients With BRCA1/2 Mutated or Homologous Recombination Deficient (HRD+) Ovarian Cancer Following Response to First Line Platinum-Based Chemotherapy

  Current Status: Open

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• A Phase II/III, Multicenter, Randomized Study of Raludotatug Deruxtecan (R-DXd), a CDH6-directed Antibody-drug Conjugate, in Subjects With Platinum-resistant, High-grade Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

  Current Status: Open

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• A Phase I/II, Open-Label, Dose-Escalation and Expansion First-In-Human Study of ATX-295, an Oral Inhibitor of the Kinesin Motor Protein KIF18A, in Patients With Locally Advanced or Metastatic Solid Tumors, Including High-Grade Serous Ovarian Cancer

  Current Status: Open

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• A Phase I First-in-Human, Open-Label Study Evaluating Safety, Pharmacokinetics, and Efficacy of ABBV-901 as a Monotherapy and in Combination in Adult Subjects With Ovarian Cancer

  Current Status: Open

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• A Phase I, First in Human Study of CTIM-76, a Claudin-6 (CLDN6)-Directed Bispecific Antibody, in Patients With Recurring Ovarian Cancer and Other Advanced Solid Tumors

  Current Status: Open

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• A Phase I First-in-Human Study of MUC16-Directed Antibody Drug Conjugate HWK-016 in Participants With Advanced Solid Tumors

  Current Status: Open

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• A Phase I Multicenter, Open-Label, Dose-Escalation and Expansion Study of NTB-928, a FRa;-Targeting Bispecific T-cell Engager, in Subjects with Relapsed/Refractory Ovarian Carcinoma

  Current Status: Open

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• A Non-Randomized Prospective Clinical Trial Comparint the Non-Inferiority of Salpingectomy to Salpingo-Oophorectomy to Reduce the Risk of Ovarian Cancer Among BRCA1 Carriers (SOROCk)

  Current Status: Open

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• NRG-GY037: A Phase III Study of Induction Pembrolizumab and Chemotherapy Followed by Chemoradiation and Pembrolizumab Versus Chemoradiation and Pembrolizumab Both Followed by Pembrolizumab for High Risk Locally Advanced Cervical Cancer

  Current Status: Open

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• The Phase III 'High Five Trial' Five Fraction Radiation For High-Risk Prostate Cancer

  Current Status: Open

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• A Randomized Phase II Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy with and without BMX-001 as part of Total Neoadjuvant Therapy in Patients with Newly Diagnosed Locally Advanced Rectal Adenocarcinoma

  Current Status: Open

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• A Phase II Study of Cabozantinib in Combination With Cemiplimab (Cabo-Cemiplimab) Versus Cabozantinib Alone in Adolescents and Adults With Advanced Adrenocortical Cancer

  Current Status: Open

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• Safety and Tolerability of Ziftomenib Combinations for the Treatment of KMT2A-rearranged or NPM1-mutant Relapsed/Refractory Acute Myeloid Leukemia

  Current Status: Open

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• Ivonescimab Combined with Chemotherapy Versus Pembrolizumab Combined with Chemotherapy for the First-line Treatment of Metastatic Squamous Non-small Cell Lung Cancer

  Current Status: Open

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• A Phase 1/2 Multi-Center Study Evaluating the Safety and Efficacy of Rondecabtagene Autoleucel, a CD19/CD20 Dual Targeting Chimeric Antigen Receptor T-Cell Therapy in Participants With Aggressive B-Cell Non-Hodgkin Lymphoma

  Current Status: Open

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• A Randomized, Phase III Study of Rilvegostomig in Combination with Fluoropyrimidine and Trastuzumab Deruxtecan versus Trastuzumab, Chemotherapy, and Pembrolizumab for the First-line Treatment of HER2-positive Gastric Cancer (ARTEMIDE-Gastric01)

  Current Status: Open

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• Phase II trial to evaluate immune-related biomarkers for pathological response in stage II-III HER2-positive breast cancer receiving neoadjuvant chemotherapy with subsequent randomization to multi-epitope HER2 vaccine vs. placebo in patients with residual disease post-neoadjuvant chemotherapy

  Current Status: Open

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• A Phase II, Open-Label, Multicenter Study of Inobrodib in Combination With Pomalidomide and Dexamethasone in Patients With Relapsed or Refractory Multiple Myeloma (CCS1477-04)

  Current Status: Open

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• A Phase II study of Ipilimumab, Cabozantinib, and Nivolumab in rare genitourinary cancers (ICONIC)

  Current Status: Open

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• A Phase II Randomized Trial to Optimize GVHD Prophylaxis After Allogeneic Hematopoietic Cell Transplantation in Older Adults With Hematological Malignancies

  Current Status: Open

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• Phase III Randomized Controlled Trial to Compare LYL314, a Dual Targeting CD19/CD20 CAR T-Cell Product Candidate, Versus Investigator's Choice of CD19 CAR T-Cell Therapy in Patients with Relapsed or Refractory Large B-Cell Lymphoma in the Second-Line Setting

  Current Status: Open

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• BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

  Current Status: Open

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• A Long-term Follow-up Study of Patients Who Received MB-105

  Current Status: Open

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• Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy

  Current Status: Open

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• The Utility of Enhanced Recovery After Surgery (ERAS) Protocols in Breast Conserving Surgery: A Randomized Control Trial

  Current Status: Open

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• Managed Access Program (MAP) Cohort Treatment Plan CCTL019B2003I to provide access for patients with out of specification leukapheresis product and/or out of specification manufactured tisagenlecleucel (CTL019; Kymriah®)

  Current Status: Open

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• ROSETTA CRC-203: A Blinded, Randomized Phase II/III Study of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer

  Current Status: Open

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• Phase III Randomized Trial of Standard Systemic Therapy (SST) versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer

  Current Status: Open

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• A Phase I, Open-Label, Multicenter Study of INCA036873 in Participants With Advanced Solid Tumors and Hematological Malignancies

  Current Status: Open

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• Phase III Randomized Trial of IO-Based Systemic Treatment +/- Liver SBRT in Hepatocellular Cancer With Macrovascular Invasion (HELIO-RT)

  Current Status: Open

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• Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder for Bladder Cancer Treatment, MODERN Study

  Current Status: Open

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• Biomarker Approach to Screening for the early detection of HPV- related Oropharyngeal Cancer (BASH OPC)

  Current Status: Open

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• High-dose rate brachytherapy boost with SBRT to prostate and pelvic nodes for the initial treatment of unfavorable intermediate or higher risk prostate cancer

  Current Status: Open

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• A Phase II Randomized Trial of Enteral Nutrition Versus Standard of Care in Allogeneic Hematopoietic Stem Cell Transplantation (ENABLE-1)

  Current Status: Open

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• A First-In-Human Multicenter, Open-Label Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-319 in B-cell Malignancies

  Current Status: Open

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• A randomized Phase II trial of adjuvant Pembrolizumab versus observation following curative resection for stage I non-small cell lung cancer (NSCLC) with primary tumors between 1-4 cm: Big Ten Cancer Research Consortium BTCRC-LUN18-153

  Current Status: Open

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• Randomized Phase III Trial of mFOLFIRINOX +/- Nivolumab vs. FOLFOX +/- Nivolumab for First-Line Treatment of Metastatic HER2-Negative Gastroesophageal Adenocarcinoma

  Current Status: Open

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• A Pilot study utilizing escitalopram to address cognitive dysfunction in Glioma patients

  Current Status: Open

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• A Master Protocol to Evaluate the Long-Term Safety of Pirtobrutinib

  Current Status: Open

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• A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation

  Current Status: Open

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• A Phase II, Open-Label, Single-Arm, Multicenter Study to Evaluate the Efficacy of Cemsidomide + Dexamethasone in Subjects With Relapsed/Refractory Multiple Myeloma

  Current Status: Open

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• Resilience in Older Adults with Leukemia Receiving Initial Treatment: The ROAR-1 Study

  Current Status: Open

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• A Phase IIa Multicenter, Dose-Escalation and Dose Optimization Study of SYNC-T Therapy SV-102 for Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

  Current Status: Open

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• A Phase II Trial of Asciminib, Dasatinib, Prednisone, and Blinatumomab for Participants with Newly Diagnosed Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia

  Current Status: Open

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• A Phase II Randomized, Multicenter Study to Evaluate the Efficacy and Safety of Silevertinib, an Oral EGFR Inhibitor, in Combination With Temozolomide in Patients With Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter and EGFRvIII

  Current Status: Open

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• A Pragmatic Randomized Phase II Trial Evaluating Total Ablative Therapy for Patients with Limited Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery (ERASur)

  Current Status: Open

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• A prospective, multicenter, open-label, randomized, actively controlled, parallel-group Phase III clinical trial to evaluate efficacy, safety, and tolerability of IMA203 versus investigator's choice in patients with previously treated, unresectable or metastatic cutaneous melanoma

  Current Status: Open

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• Randomized, Open-label, Multicenter, Phase II Study Evaluating the Efficacy and Safety of Zilovertamab Vedotin (MK-2140) Plus R-CHP Versus Polatuzumab Vedotin Plus R-CHP in Treatment-naïve Participants With GCB Subtype of Diffuse Large B-cell Lymphoma (DLBCL)

  Current Status: Open

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• A Phase III Randomized, Open-Label, Multicenter Study of Sonrotoclax Plus Anti-CD20 Antibody Therapies Versus Venetoclax Plus Rituximab in Patients With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

  Current Status: Open

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• ResQ132EX-NMIBC: Expanded Access Use of Recombinant Bacillus Calmette-Guérin in Nonmuscle Invasive Bladder Cancer

  Current Status: Open

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• Consolidative Use of Radiotherapy to Block (CURB2) Oligoprogression In Patients With Metastatic Non-Small-Cell Lung Cancer

  Current Status: Open

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• A Phase III, Open-Label, Randomized Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared with Venetoclax Plus Acalabrutinib in Patients with Previously Untreated Chronic Lymphocytic Leukemia

  Current Status: Open

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• MYELOMATCH, Master Screening and Reassessment Protocol for Tier Advancement in the NCI myeloMATCH Clinical Trials

  Current Status: Open

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• A Phase I Study of IM-1021 in Participants with Advanced Malignancies

  Current Status: Open

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• OptimICE-PCR: De-Escalation of Therapy in Early-Stage TNBC Patients Who Achieve pCR After Neoadjuvant Chemotherapy with Checkpoint Inhibitor Therapy

  Current Status: Open

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• Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

  Current Status: Open

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• A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Dedifferentiated Liposarcoma (DDLPS), Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas

  Current Status: Open

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• Expanded Access Study for the Treatment of Patients with Commercially Out-of-Specification Axicabtagene Ciloleucel

  Current Status: Open

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• Phase II Study of Cytarabine + Daunorubicin (7 + 3) + Gemtuzumab Ozogamicin vs. Cytarabine + Daunorubicin (7 + 3) + Venetoclax for the Treatment of Newly Diagnosed Core Binding Factor Acute Myeloid Leukemia (CBF-AML) in Younger Adults: A MyeloMATCH Substudy

  Current Status: Open

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• Expanded Access Protocol (EAP) For Patients Receiving Lisocabtagene Maraleucel That Is Nonconforming For Commercial Release

  Current Status: Open

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• A Measurable Residual Disease (MRD) Driven, Phase II Study of Venetoclax Plus Chemotherapy for Newly Diagnosed Younger Patients With Intermediate Risk Acute Myeloid Leukemia: A Tier 1 MYELOMATCH Clinical Trial

  Current Status: Open

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• A Phase III Randomized, Open Label, Multicenter Study to Evaluate the Safety and Efficacy of ABBV-706 Versus Standard of Care in Subjects With Relapsed/Refractory Small Cell Lung Cancer (SCLC)

  Current Status: Open

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• A Phase III Randomized, Open-label Study of MK-5684 Versus Alternative Abiraterone Acetate or Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) Previously Treated With Next-generation Hormonal Agent (NHA) and Taxane-based Chemotherapy

  Current Status: Open

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• Targeted Agent and Profiling Utilization Registry (TAPUR) Study

  Current Status: Open

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• A Phase II Study of Venetoclax, Ibrutinib, Prednisone, Obinutuzumab, and Revlimid (ViPOR) in Relapsed or Refractory CD10-Negative Diffuse-Large B-Cell Lymphoma (DLBCL) and High-Grade B-Cell Lymphoma with MYC and BCL2 rearrangements (HGBCL-DH-BCL2)

  Current Status: Open

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• Halt Aging in Survivors of Blood Cancers: the HALTAging-1 Study

  Current Status: Open

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• A Phase I/II Study of Inhaled KB707 in Patients with Advanced Solid Tumor Malignancies Affecting the Lungs

  Current Status: Open

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• A Randomized Phase III Study of Neoadjuvant Chemotherapy Followed by Surgery Versus Surgery Alone for Patients with High Risk RetroPeritoneal Sarcoma (STRASS 2)

  Current Status: Open

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• Expanded Access Program for Mezigdomide (in combination with Carfilzomib/dex or Bortezomib/dex) for Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

  Current Status: Open

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• A Phase III, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084, Cetuximab, and mFOLFOX6 Versus mFOLFOX6 With or Without Bevacizumab as First-line Treatment of Participants With KRAS G12C-mutant, Locally Advanced Unresectable or Metastatic Colorectal Cancer (KANDLELIT-012)

  Current Status: Open

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• A Randomized, Double-Blind, Active-Control, Multicenter Phase III Trial of Casdatifan and Cabozantinib Versus Placebo and Cabozantinib in Patients With Advanced Clear Cell Renal Cell Carcinoma

  Current Status: Open

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• A Phase III, Multicenter, Randomized, Open-label Study of Ifinatamab Deruxtecan (I-DXd), a B7-H3 Antibody Drug Conjugate (ADC), Versus Treatment of Physician's Choice (TPC) in Subjects With Relapsed Small Cell Lung Cancer (SCLC) (IDeate-Lung02)

  Current Status: Open

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• A Phase III Study of Cabazitaxel with or without Carboplatin in Patients with Metastatic Castrate-resistant Prostate Cancer (MCrPC), Stratified by Aggressive Variant Signature (CARAVAN)

  Current Status: Open

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• A Randomized, Multicenter, Placebo-controlled, Phase III Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects With Residual Disease or High-Risk PCR After Both Neoadjuvant and Postoperative Adjuvant Trastuzumab-based Therapy (FLAMINGO-01)

  Current Status: Open

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• A Phase I, multicenter, open-label study of UB-VV111 in combination with Rapamycin in relapsed or refractory (R/R) CD19+ B-Cell malignancies

  Current Status: Open

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• An Open-Label, Dose Escalation and Dose Expansion Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients with Relapsed or Refractory Primary Central Nervous System Lymphoma

  Current Status: Open

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• Establishment of a national biorepository to advance studies of immune-related adverse events

  Current Status: Open

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• PSMA-PET Guided De-escalation of Salvage Radiation Treatment in Patients with Recurrent Prostate Cancer After Prostatectomy

  Current Status: Open

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• A Randomized Phase III Trial of Continuous vs. Intermittent Maintenance Therapy with Zanubrutinib as Upfront Treatment in Older Patients with Mantle Cell Lymphoma (INTERCON)

  Current Status: Open

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• Feasibility of de-escalation of axillary surgery in ycN0 breast cancer patients post NAC for cN2, cN3 disease: evaluating the concordance between ypN status from TAD and ALND

  Current Status: Not Open

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• Treatment practices and outcomes of adults with therapy-related acute myeloid leukemia (AML) and AML with myelodysplasia related changes

  Current Status: Open (affiliates Only)

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• A Phase II/III, Multicenter, Randomized Open-Label Study of Zanzalintinib vs Everolimus in Participants With Previously Treated, Unresectable, Locally Advanced or Metastatic Neuroendocrine Tumors

  Current Status: Open

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• A Study of Cemiplimab Plus Chemotherapy Versus Cemiplimab Plus Chemotherapy Plus Other Cancer Treatments for Adult Patients With Operable Non-Small Cell Lung Cancer (NSCLC)

  Current Status: Open

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• Abiraterone/Prednisone + Standard ADT vs Standard ADT for Prostate Cancer Patients with PSMA-Positive Conventionally Negative Pelvic Lymphadenopathy

  Current Status: Open

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• A Randomized Study Evaluating GLIADEL Compared to Stereotactic Radiosurgery in Patients with Metastatic Brain Disease

  Current Status: Open

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• Implementation of the New Pediatric Obesity Clinical Practice Guideline in Rural Families and Clinics: A Randomized Clinical Trial

  Current Status: Open

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• A Phase II Study of Combined Amivantamab, Carboplatin and Paclitaxel in Unresectable Locally Recurrent or Metastatic Head and Neck Cancer

  Current Status: Open

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• Inotuzumab Ozogamicin Post-Transplant For Acute Lymphocytic Leukemia and Non-Hodgkin's Lymphoma

  Current Status: Open

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• A Phase I Study of Metronomic Temozolomide with PCI-24781 for Patients with Recurrent High Grade Glioma

  Current Status: Open

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• A Pilot, Randomized, Double-blind, Placebo-controlled Study using Prebiotics to Improve Gut Microbiome Diversity After Autologous Cellular Therapy in Multiple Myeloma and Lymphoma: The PRIMAL Trial

  Current Status: Open

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• A Phase I Multicenter, Open-Label Study to Determine the Recommended Dose and Evaluate the Safety and Preliminary Efficacy of BMS-986393 in Novel Combinations in Participants with Relapsed and/or Refractory Multiple Myeloma and Determine the Recommended Dose For Each Add On Investigational Component

  Current Status: Open

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• Shorter Anthracycline-Free Chemo Immunotherapy Adapted to Pathological Response in Early Triple Negative Breast Cancer (SCARLET), A Randomized Phase III Study

  Current Status: Open

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• A Randomized, Open-Label, Phase II/III Study of Datopotomab-Deruxtecan (Dato-DXd) plus Carboplatin or Cisplatin versus Gemcitabine plus Carboplatin or Cisplatin in Subjects with Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC) who progressed during or after Enfortumab Vedotin (EV) plus Pembrolizumab Combination Treatment. TROPIONUrothelial03 (TU03).

  Current Status: Not Open

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• Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25 (OFSET)

  Current Status: Open

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• PADL1NK-005: A Randomized, Phase 3, Open-Label Study to Evaluate PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

  Current Status: Open

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• ShortStop-HER2: Shortened Duration of Adjuvant Therapy in Patients With Early-Stage HER2+ Breast Cancer Who Achieve pCR After Neoadjuvant Chemotherapy With HER2 Blockade

  Current Status: Open

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• A Phase III, Randomized Study of Daratumumab, Cyclophosphamide, Bortezomib and Dexamethasone (Dara-VCD) Induction Followed by Autologous Stem Cell Transplant or Dara-VCD Consolidation and Daratumumab Maintenance in Patients with Newly Diagnosed AL Amyloidosis

  Current Status: Open

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• Phase III, Randomized, Open-label, Global, Multicenter Study of Rilvegostomig or Durvalumab in Combination With Chemotherapy as a First-line Treatment for Patients With Advanced Biliary Tract Cancer (ARTEMIDE-Biliary02)

  Current Status: Not Open

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