Most people who require medical treatment for trigeminal neuralgia begin with medications. Typical pain medications such as aspirin, acetaminophen or narcotic medications such as codeine, may provide partial relief of pain but usually several types of medications are needed for adequate pain relief. Medications that have proven most useful are the “anticonvulsant” medications, which seem to have a direct effect in reducing the frequency and severity of attacks of trigeminal neuralgia. Another medication, called baclofen, may be useful for some individuals. No single medication works best for all people, and your doctor may need to try several to find which ones work best for you.