Evaluation of changes in brain connectivity after tumor resection
Categories (click each to see list of all clinical trials associated with that category): Brain/Neuro (ONC)
Current Status: Open
Phase: N/A
Principal Investigator: Aizenberg-Ansari, Michele
Eligibility: https://clinicaltrials.gov/study/NCT04536142?term=NCT04536142&rank=1
Summary
1. Assess the correlations between the structural connectivity, functional connectivity, and neurocognitive changes occurring after brain tumor removal. We hypothesize that the structural and functional connectivity will be altered from pre-operative baseline as a result of the removal of the tumor.
1A: We will analyze diffusion-MRI to determine changes in structural connectivity after removal of a brain tumor. We expect to see changes that correlate with neurocognitive status.
1B: We will analyze resting state-MRI to determine changes in functional connectivity after brain tumor removal. We expect to see changes that correlate with neurocognitive status.
1C: We will assess the correlation of structural and functional changes to each other.
We expect to see correlations between changes in structural and functional connectivity.
2: Examine the effects of tumor location, tumor size, tumor type, patient age, and sex on surgically induced changes in brain connectivity and neurocognitive status. These variables may alter the capacity of brain re-organization and plasticity. We hypothesize that connectivity changes will be significantly impacted by one or more of these variables.