Screening for Resistant Enteric Bacteria to Personalize Infection Prevention Strategies in Neutropenic Patients
Categories (click each to see list of all clinical trials associated with that category): Leukemia/MDS/MPD (ONC)
Current Status: Open
Phase: N/A
Principal Investigator: Freifeld, Alison
Contact Information:
Michelle Desler
+1 402-559-8885
mdesler@unmc.edu
Eligibility: https://www.clinicaltrials.gov/study/NCT04710212?term=NCT04710212&rank=1
Summary
This is a prospective, observational cohort study to assess the frequency with which neutropenic patients with hematologic malignancies are colonized with fluoroquinolone-resistant Enterobacterales (FQRE) and the clinical impact of FQRE colonization. We will collect perianal swabs from patients receiving induction chemotherapy for acute leukemia or undergoing hematopoietic stem cell transplantation (HCT), and who are scheduled to receive fluoroquinolone (FQ) prophylaxis. FQRE colonization will be assessed by culture and molecular methods, and we will correlate FQRE colonization with the risk of Gram-negative bacteremia during neutropenia.
Primary Objective: Compare the risk of Gram-negative bloodstream infection (BSI) despite FQ prophylaxis during neutropenia in patients colonized with FQRE compared to patients not colonized with FQRE