Dr. Langnas received his undergraduate degree from the University of Michigan and medical education at the Kansas City University of Medicine and Biosciences. He began his internship at Botsford General Hospital in Farmington Hills, Michigan in 1982. In 1987 he began his transplantation fellowship at Henry Ford Hospital and completed a second year of fellowship training at the University of Nebraska Medical Center. On completion of his fellowship in 1989 he joined the faculty of the University of Nebraska Medical Center. Dr. Langnas is currently a Professor of Surgery at the University of Nebraska Medical Center. He has been Chief of the Section of Transplantation Surgery and the Director of the Transplantation Fellowship at the University of Nebraska Medical Center since 1997.
Awards & Honors
- Alumni Achievement Award Kansas City University of Medicine and Biosciences (2004)
- Transplant Fellows teaching award (1995)
- Merck Sharp and Dome - Annual Resident Achievement Award (1986-1987)
- Alvin Yarrow's Award - Certificate of Excellence (1986)
- Integrated Therapeutics, Mukherjee (PI), 2006-Present
PROTECT- Pegylated Interferon Alfa-2B and Ribavirin after Orthotopic Liver Transplantation: Efficacy and Safety in Hepatitis C Recurrence Therapy
The major goal of this research study is to evaluate the effectiveness and safety of Pegylated interferon alfa-2b in combination with ribavirin in patients whose hepatitis c virus has recurred after liver transplantation.
- Novartis Pharmaceuticals Corp, Mukherjee (PI), 2006-Present
A Multicenter, Randomized, Open Label Study to Compare the Development of Liver Fibrosis at 12 Months After Transplantation for Hepatitis C Cirrhosis in Patients Receiving either Neoral or Tacrolimus
The major goal of this research study is to see if the time to recurrence of liver fibrosis is longer with Neoral than Tacrolimus.
- Genzyme Corporation, Grant (PI), 2005-Present
A Randomized, Single-Center Trial Comparing Thymoglobulin Induction Therapy and Delayed Initiation of Tacrolimus to No Induction with Immediate Initiation of Tacrolimus in Liver Transplant Recipients to Assess the Impact on Renal Function
The major goal of this research study is explore Thymoglobulin induction and its impact on renal function in liver transplant patients.
Role: Co- Investigator
- NIH/NIDDK, Langnas (PI), 2005-Present
Functional Outcomes in Pediatric Liver Transplantation
The major goal of this project is to compare health-related quality of life of children who have had liver transplants to that of children in the general population.
Role: Principal Investigator
- NIH/NIDDK, Langnas (PI), 2004-Present
SPLIT (Studies of Pediatric Liver Transplantation), A Multicenter, Prospective Study to Collect Scientific Data on Pediatric Liver Transplantation
The major goal of this research is designed to characterize and follow trends and indications for transplant, transplant techniques, and outcomes of pediatric isolated liver transplant recipients into one registry.
Role: Principal Investigator
- Novartis Pharmaceuticals, Langnas (PI), 2004-Present
A Facilitated Access Program to Provide Everolimus (RAD) for Maintenance Patients Completing Therapy in RAD Trials in Solid Organ Transplantation
The major goal of this research is to continue to monitor long-term safety and efficacy of Everolimus in recipients of solid organ transplants.
Role: Principal Investigator
- Wyeth Research, Grant (PI), 2002-Present
A Randomized, Open-Label, Comparative Evaluation of Conversion from Calcineurin Inhibitor (CI) Treatment to Sirolimus Treatment versus Continued Calcineurin Inhibitor Treatment in Liver Allograft Recipients Undergoing Maintenance Therapy
The major goal of this research is to determine whether kidney function can be protected through the use of Sirolimus maintenance therapy alone without increasing the risk of rejection.
Publications, Most Recent:
- Cytomegalovirus viremia in solid organ transplantation: does the initial viral load correlate with risk factors and outcomes?
Levitsky J, Freifeld AG, Puumala S, Bargenquast K, Hardiman P, Gebhart C, Wrenshall L, Langnas A, Kalil AC.
Clin Transplant. 2008 Mar-Apr;22(2):222-8.
PMID: 18339143 [PubMed - indexed for MEDLINE]
- Comparison of intestinal lengthening procedures for patients with short bowel syndrome.
Sudan D, Thompson J, Botha J, Grant W, Antonson D, Raynor S, Langnas A.
Ann Surg. 2007 Oct;246(4):593-601; discussion 601-4.
PMID: 17893496 [PubMed - indexed for MEDLINE]
- Role of an intestinal rehabilitation program in the treatment of advanced intestinal failure.
Torres C, Sudan D, Vanderhoof J, Grant W, Botha J, Raynor S, Langnas A.
J Pediatr Gastroenterol Nutr. 2007 Aug;45(2):204-12.
PMID: 17667717 [PubMed - indexed for MEDLINE]
- Calprotectin: a novel noninvasive marker for intestinal allograft monitoring.
Sudan D, Vargas L, Sun Y, Bok L, Dijkstra G, Langnas A.
Ann Surg. 2007 Aug;246(2):311-5.
PMID: 17667511 [PubMed - indexed for MEDLINE]
- Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantation.
Botha JF, Thompson E, Gilroy R, Grant WJ, Mukherjee S, Lyden ER, Fox IJ, Sudan DL, Shaw BW Jr, Langnas AN.
Liver Int. 2007 Aug;27(6):758-63.
PMID: 17617118 [PubMed - indexed for MEDLINE]
- A novel approach to generate host antitumor T cells: adoptive immunotherapy by T cells maturing in xenogeneic thymus.
Zhao Y, Sun Y, Niu Z, Li Q, Peng J, Wang J, Langnas AN.
J Immunother. 2007 Jan;30(1):83-8.
PMID: 17198086 [PubMed - indexed for MEDLINE]
- Liver transplantation for hepatocellular carcinoma: an update.
Botha JF, Langnas AN.
J Natl Compr Canc Netw. 2006 Sep;4(8):762-7. Review.
PMID: 16948954 [PubMed - indexed for MEDLINE]
- Isolated liver transplantation in infants with end-stage liver disease due to short bowel syndrome.
Botha JF, Grant WJ, Torres C, Iverson AK, Sudan DL, Shaw BW Jr, Langnas AN.
Liver Transpl. 2006 Jul;12(7):1062-6.
PMID: 16710856 [PubMed - indexed for MEDLINE]
- Inflammatory bowel disease after liver transplantation: risk factors for recurrence and de novo disease.
Should Follow Hyperlink
Verdonk RC, Dijkstra G, Haagsma EB, Shostrom VK, Van den Berg AP, Kleibeuker JH, Langnas AN, Sudan DL.
Am J Transplant. 2006 Jun;6(6):1422-9.
PMID: 16686766 [PubMed - indexed for MEDLINE]
- Hepatobiliary cancers. Clinical practice guidelines in oncology.
Benson AB 3rd, Bekaii-Saab T, Ben-Josef E, Blumgart L, Clary BM, Curley SA, Davila R, Earle CC, Ensminger WD, Gibbs JF, Laheru D, Langnas AN, Mulvihill SJ, Nemcek AA Jr, Posey JA, Sigurdson ER, Sinanan M, Vauthey JN, Venook AP, Wagman LD, Yeatman TJ; National Comprehensive Cancer Network.
J Natl Compr Canc Netw. 2006 Sep;4(8):728-50. No abstract available.
PMID: 16948952 [PubMed - indexed for MEDLINE]
- Safety, tolerability, and efficacy of everolimus in de novo liver transplant recipients: 12- and 36-month results.
Levy G, Schmidli H, Punch J, Tuttle-Newhall E, Mayer D, Neuhaus P, Samuel D, Nashan B, Klempnauer J, Langnas A, Calmus Y, Rogiers X, Abecassis M, Freeman R, Sloof M, Roberts J, Fischer L.
Liver Transpl. 2006 Nov;12(11):1640-8. Erratum in: Liver Transpl. 2006 Nov;12(11):1726.
PMID: 16598777 [PubMed - indexed for MEDLINE]
- Speaker: Managed Clinical Networks, Liver & Small Bowel Transplantation. "Innovations in Liver Small Bowel Transplantation, What Will the Future Hold?" Kings College, London, England (November 5-8, 2008)
- Speaker: Grand Rounds, Lahey Clinic. "Renal Insufficiency in Liver Transplantation" Burlington, MA (October 16-17, 2008)
- Speaker: The 17th Annual National Clinical Conference, Optum Health. "Living Donor Liver Transplantation: Where are we now?" Minneapolis, MI (September 21-23, 2008)
- Speaker: Nebraska Medicine/Optum Health Care Solutions', Extraordinary Innovations in Transplantation and Oncology. "Organ Transplantation at Nebraska Medicine: Innovations, Challenges and Trends". Omaha, NE (July 22, 2008)
- Speaker: Iowa Osteopathic Medical Association, 2008 Midwest Surgical Update. "Surgical Options in the Treatment of Intestinal Failure: No Place for a Procrustean Bed". Des Moines, IA (May 2-3, 2008)
- Speaker: 9th Annual: Management of Transplantation and Other Complex Medical Conditions. Boston, MA (April 29-May 2, 2008)
- Speaker: Dallas Baylor University. "Liver Transplantation Colon Post Operative Renal Function and Role of Rabbit Anti-Thymocyle Globulin ". Dallas, TX (April 23, 2008).
- Speaker: ASTS 8th Annual State of the Art Winter Symposium: The High Risk Recipient. "Won't Get Fooled Again": Liver Retransplantation for Hepatitis C. Marco Islands, FL (January 23-27, 2008)
- J.H. Lowe Visiting Professor, Department of Surgery, University of Capetown. Capetown, South Africa (October 22-26, 2007)
- Speaker: Hepato-Pancreato-Biliary Society of South Africa Congress and operative workshop. University of Witwatersrand, Johannesburg, South Africa. (October 12-19, 2007)
- Speaker: 16th Annual National Clinical Conference, United Resource Networks. "Clinical Outcomes Following Intestinal Transplantation". Minneapolis, MN (October 2, 2007)
Professional Organization Memberships:
- American Surgical Association
- American College of Surgeons, Fellow
- The Society of University Surgeons
- American Association for the Study of Liver Disease
- American College of Gastroenterology
- American Society of Transplant Physicians
- American Society of Transplant Surgeons
- Association for Academic Surgery
- International College of Surgeons, Fellow
- International Liver Transplantation Society
- The Society for Surgery of the Alimentary Tract
- The Southwestern Surgical Congress, Fellow
- The Transplantation Society
- American Osteopathic Association
- Transplant Recipients International Organization, Inc