Cancer
- About Cancer
- Cancer and Genetics
- Cancer and Nutrition
- Cancer Diagnosis
- Cancer Test and Procedures
- Cancer Treatment
- Cancer Treatment Side Effects
- Living With Cancer
-
Specific Cancers
- Adrenal Cancer
- Anal Cancer
- Bile Duct Cancer
- Bladder Cancer
- Bone Cancer
- Brain and Central Nervous Cancer
- Breast Cancer
- Carcinoma of Unknown Primary
- Cervical Cancer
- Colorectal Cancer
- Endometrial Cancer
- Esophageal Cancer
- Ewing Sarcoma
- Eye Cancer
- Gallbladder Cancer
- Head and Neck Cancer
- Hodgkin Disease
- Kaposi's Sarcoma
- Kidney Cancer
- Laryngeal Cancer
- Leukemia - Acute Lymphocytic Leukemia (ALL)
- Leukemia - Acute Myelocytic (AML)
- Leukemia - Chronic Lymphocytic Leukemia (CLL)
- Leukemia - Chronic Myelogenous Leukemia (CML)
- Leukemia - General
- Liver Cancer
- Lung Cancer
- Malignant Mesothelioma
- Multiple Myeloma
- Non-Hodgkin Lymphoma
- Oral Cancer
- Other Cancers
- Ovarian Cancer
- Pancreatic Cancer
- Penile Cancer
- Pituitary Cancer
- Prostate Cancer
- Skin Cancer - Melanoma
- Skin Cancer - Non-Melanoma
- Soft Tissue Sarcoma
- Stomach Cancer
- Testicular Cancer
- Thymus Cancer
- Thyroid Cancer
- Urethral Cancer
- Uterine Cancer
- Vaginal Cancer
- Vulvar Cancer
Genetics and Cancer - X-Linked Inheritance
Genes are the blueprints for making proteins, the substances our bodies need to develop and work properly. Most genes come in pairs, one of which is inherited from the mother and the other from the father. A mutation is a change in a gene that prevents it from working properly. Mutations in genes are inherited from our biological parents in specific ways. One of the basic patterns of inheritance of our genes is called X-linked inheritance.
What is X-linked inheritance?
X-linked inheritance means that the gene alteration causing the trait or the disorder is located on the X chromosome. Remember, females have two X chromosomes, while males have one X and one Y. Mutations in X chromosome genes can be recessive or dominant. Their expression in females and males is not the same because the genes on the Y chromosome do not exactly pair up with the genes on the X. In general, X-linked recessive mutations are expressed in females only if a female has two copies of the mutation (one on each X chromosome). However, for males, if their only copy of the X chromosome contains a mutation, they will have the trait or disorder. To date, no cancer susceptibility genes have been identified on the X chromosome. However, research studies of families with a strong history of prostate cancer have found evidence that there might be a prostate cancer susceptibility gene on this chromosome.
