Thrombocythemia
What is thrombocythemia?
Thrombocythemia is a myeloproliferative disorder. It is characterized by the production of too many platelets in the bone marrow. Too many platelets make normal clotting of blood difficult.
What causes thrombocythemia?
There may be no single cause for thrombocythemia. It is believed that in most patients it is caused by mutations to megakaryocytes, the platelet-making cells in the bone marrow.
What are the symptoms of thrombocythemia?
The following are the most common symptoms of thrombocythemia. However, each individual may experience symptoms differently. Symptoms may include:
Increased blood clots in arteries and veins
Bleeding
Bruising easily
Bleeding from the nose, gums, and gastrointestinal tract
Bloody stools
Hemorrhaging after injury or surgery
Weakness
Enlarged lymph nodes
The symptoms of thrombocythemia may resemble other blood disorders or medical problems. Always consult your physician for a diagnosis.
How is thrombocythemia diagnosed?
In addition to a complete medical history and physical examination, diagnostic procedures for thrombocythemia may include additional blood tests to measure blood counts and elevated platelet levels. Bone marrow biopsy (the marrow may be removed by aspiration or a needle biopsy under local anesthesia) may also be necessary.
Treatment for thrombocythemia
Specific treatment for thrombocythemia will be determined by your physician based on:
Your age, overall health, and medical history
Extent of the disease
Your tolerance for specific medications, procedures, or therapies
Expectations for the course of the disease
Your opinion or preference
Treatment may include:
Chemotherapy, most often with hydrea, an oral chemotherapy drug
Plateletpheresis, a procedure to remove extra platelets from the blood
