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Serious Medicine. Extraordinary Care.

Mark Edmund Rupp, M.D.

Mark E. Rupp, M.D.
Contact Information:
984031 Nebraska Medical Center
Omaha, NE 68198-4031
Phone: (402) 559-5276
Fax: 402-559-8300
Email: merupp@unmc.edu

Education

1985, M.D., Baylor College of Medicine, Houston, Texas
1981, B.S., Chemical Engineering, University of Texas, Austin, Texas


Postdoctoral Training

7/88 - 6/91 Fellowship in Infectious Diseases
Medical College of Virginia / Virginia Commonwealth University,
Richmond, Virginia

7/85 - 6/88 Residency in Internal Medicine
Medical College of Virginia / Virginia Commonwealth University
Richmond, Virginia

Current Position

  • Professor, Department of Internal Medicine, Section of Infectious Diseases University of Nebraska Medical Center
  • Medical Director, Department of Healthcare Epidemiology-Infection Control
  • Medical Director - Interim, Antimicrobial Stewardship Program The Nebraska Medical Center
  • Medical Director, Clinical Trials Office

Recent Grant Funding

  • 2009 Effectiveness of chlorhexidine gluconate (CHG) general skin cleansing in reducing the occurrence of catheter-associated bloodstream infections and the transmission and/or infection rate due to multi-drug resistant organisms in hospitalized patients. Molnlycke Health Care US. $120,000; ($708,000 product cost) P.I. M.E. Rupp
  • 2008 Dedicated patient stethoscopes for Nebraska Medical Center - demonstration of rationale and healthcare worker acceptance. 3M Inc, ($50,000 in-kind support), P.I. M.E. Rupp
  • 2008-2009 NIH-NIAID (1 R43 AI074161-01) "Novel inhibitors of Staphylococcal Biofilm Formation" Subcontract with Microbiotix, Inc. UNMC PI: M. E. Rupp. $107,040.
  • 2005-2009 NIH-NIAID (HHSN266200400066C) AI-40066 "Population Genetics Analysis on West Nile Virus" Project PI: Mark Loeb, McMaster University; UNMC site PI: M.E. Rupp, UNMC budget $662,609.
  • 2007 University of Nebraska Medical Center, College of Medicine, Faculty Educational Support Grant "Development of a Web-based Educational Program in Antimicrobial Stewardship."$5,000. Co-PI: M E Rupp, E D Hermsen.
  • 2006 Edna Ittner Pediatric Research Grant. "Characterization of Staphylococcus epidermidis Neonatal Sepsis Isolates." 09/01/2006 - 08/31/2007. $40,000; PI Paul Fey, Co-I M.E.Rupp.
  • 2006 The efficacy of daptomycin, using in-vitro and in-vivo methodologies, to eradicate PIA (biofilm)-producing Staphylococcus epidermidis. Cubist Pharmaceuticals. P.I. Fey; co-I Rupp ME.
  • 2006 Staphylococcus aureus Infections Following Cardiac Surgery. Duke Clinical Research Institute - sponsored by Merck Pharmaceuticals. Site PI ME Rupp.
  • 2005-2008 NIH-NIAID (HHSN266200400066C) AI-40066 "Population Genetics Analysis on West Nile Virus" Project PI: Mark Loeb, McMaster University; UNMC site PI: M.E. Rupp
  • 2005 Effect of Introduction of a Safety-Engineered Blood Collection Set on Activation Compliance and Sharps Injuries, Becton, Dickinson, & Co. P.I. M. E. Rupp
  • 2005 Multicenter, Randomized Trial Comparing the Moisture Handling Ability of Two Central Venous Catheter Transparent Adhesive Dressings During Diaphoretic Episodes, 3M Health Care, P.I. ME Rupp.
  • 2003 Initial Safety and Pharmacokinetic Trial of Immune Globin to Staphylococcus aureus Capsule Polysaccharide (Altastaph) in Subjects with Persistent S. aureus Bacteremia. NABI Biopharmaceuticals, P.I ME Rupp
  • 2002-2006 NIH-NIAID, 5RO1 AI49311 "ica phase variation in Staphylococcus epidermidis" Co-I: M.E. Rupp (P.I. Fey)
  • 2002-2005 Department of Veterans Affairs, "Pathogenesis of Orthopedic Prosthetic Device Infections" Co-PI: M.E. Rupp (P.I. K. Garvin)
  • 2002 Phase 3, multicenter, randomized, open-label, comparative study to assess the safety and efficacy of daptomycin compared to conventional therapy in the treatment of subjects with infective endocarditis and complicated bacteremia due to Staphylococcus aureus. Cubist Pharmaceuticals, P.I. ME Rupp

Honors & Awards

  • 2008 American College of Physicians, Nebraska Chapter, Laureate Award
  • 2006 Nebraska Medical Center "Physician of Distinction" for Medical Leadership
  • 2004-06 Treasurer, Society for Healthcare Epidemiology of America, Board of Directors
  • 2002 Elected to Membership, Alpha Omega Alpha - National Honor Medical Society
  • 2002 Selected to "Best Doctors in America", 2002, 2003, 2004, 2005, 2006, 2007
  • 2002 Chairman, American Society for Microbiology, Division L
  • 2002 "Top Teacher" Dept Internal Medicine, 2002, 2003, 2005, 2007, 2008
  • 2002-04 Academic Councilor, Society for Healthcare Epidemiology of America
  • 2001 Elected to Fellowship, Infectious Diseases Society of America
  • 2001 UNMC College of Medicine Dean's Award for Special Achievement, 2002, 2004, 2007
  • 2000 Blue Ribbon Award - for meritorious abstract at the 27th Annual Meeting of the Association for Professionals in Infection Control
  • 2000 Continuous Appointment (Tenure), University of Nebraska Medical Center
  • 1993 National Foundation for Infectious Diseases Young Investigator Award

Membership in Professional Societies

ACP American College of Physicians (Fellow), IDSA Infectious Diseases Society of America (Fellow), ASM American Society of Microbiology (Member), SHEA Society for Hospital Epidemiology of America (Fellow, President 2009), CSCR Central Society for Clinical Research (Member), International Society on Staphylococci and Staphylococcal Infections (Member), HIS Hospital Infection Society (Member), MOMS Metro Omaha Medical Society (Member), ACPE American College of Physician Executives (Member)

Selected Publications: (Total Bibliography: 100 articles, 1 textbook, 31 chapters, 146 abstracts, 3 patents, 1 software program, 51 other - book reviews, letters to editor, published interviews, etc)

Articles

  • Iwen PC, Kelly DM, Linder J, Hinrichs SH, Dominguez EA, Rupp ME, Patil KD. Change in prevalence and antibiotic resistance of Enterococcus species isolated from blood cultures over an 8-year period. Antimicrobial Agents Chemotherapy. 41:494-5, 1997.
  • Dominguez EA, Davis JC, Langnas AN, Winfield B, Cavalieri SJ, Rupp ME. An outbreak of vancomycin-resistant Enterococcus faecium in liver transplant recipients. Liver Transplantation and Surgery. 3:1-6, 1997.
  • Rupp ME, Hamer KE. Effect of subinhibitory concentrations of ofloxacin, levofloxacin, d-ofloxacin, vancomycin, and cefazolin on the adherence to intravascular catheters and biofilm formation by Staphylococcus epidermidis. Journal of Antimicrobial Chemotherapy, 41:155-161, 1998.
  • Smith TL, Iwen PC, Olson S, Rupp ME. Environmental contamination with vancomycin-resistant Enterococci in an outpatient setting. Infection Control and Hospital Epidemiology. 19:515-518, 1998.
  • Bergman KL, Olsen KM, Peddicord TE, Fey PD, Rupp ME. Comparative study of antimicrobial activity and postantibiotic effect of physiologic levels of clarithromycin, 14-hydroxyclarithromycin, and azithromycin against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy, 43:1291-93, 1999.
  • Ratanasuwan W, Iwen PC, Hinrichs SH, Rupp ME. Bacteremia due to motile Enterococcus species: clinical features and outcomes. Clinical Infectious Diseases, 28:1175-77, 1999.
  • Iwen PC, Rupp ME, Schreckenberger PC, Hinrichs SH. Evaluation of the revised Microscan dried overnight gram-positive panel to identify Enterococcus species. Journal of Clinical Microbiology. 37:3756-3758, 1999.
  • Bergman KL, Olsen KM, Rupp ME. Relevance of pulmonary tissue concentrations of macrolide antibiotics. Recent Research Developments in Antimicrobial Agents and Chemotherapy. 3:271-279, 1999.
  • Olsen KO, Peddicord TE, Campbell GD Jr, Rupp ME. Antimicrobial effect of lidocaine in bronchoalveolar lavage fluid. Journal of Antimicrobial Chemotherapy. 45:217-19, 2000.
  • Fey PD, Safranek TJ, Rupp ME, Dunne EF, Ribot E, Iwen PC, Bradford PA, Angulo FJ, Hinrichs SH. Pediatric ceftriaxone-resistant Salmonella infection acquired from infected cattle in the United States. New England Journal of Medicine. 342:1242-1249, 2000.
  • Rebuck JA, Olsen KM, Fey PD, Bergman KL, Rupp ME. In vitro activity of parenteral beta-lactam antimicrobials against TEM-10, TEM-26, and SHV-5 derived extended-spectrum beta-lactamases. Journal Antimicrobial Chemotherapy. 46:461-64, 2000.
  • Rebuck JA, Olsen KM, Fey PD, Langnas AN, Rupp ME. Characterization of an extended spectrum beta-lactamase outbreak in a pediatric intensive care unit solid organ transplant population. Clinical Infectious Diseases. 31:1368-72, 2000.
  • Rupp ME, Marion N, Fey PD, Bolam DL, Iwen PC, Overfelt CM, Chapman L. Outbreak of vancomycin-resistant enterococci in a neonatal intensive care unit. Infection Control and Healthcare Epidemiology. 22:301-03, 2001.
  • Olsen KM, Rebuck J, Rupp ME. Arthralgias and myalgias associated with Quinupristin/Dalfopristin administration. Clinical Infectious Diseases. 32:e83-86, 2001.
  • Carver PL, Nicolau DP, Rupp ME, Turner AL . American Pharmaceutical Association Special Report: Combating Antibiotic Resistance. 1-20, 2001.
  • Caratoli A, Tosini F, Giles WP, Rupp ME, Hinrichs SH, Angulo FJ, Barrett TJ, Fey PD. Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella isolated in the United States between 1996 and 1998. Antimicrobial Agents and Chemotherapy. 46:1269-1272, 2002.
  • Fey PD, Salim B, Rupp ME, Hinrichs SH, Boxrud DJ, Davis CC, Kreiswirth BN, Schlievert PM. Comparative molecular analysis of community-acquired methicillin-resistant Staphylococcus aureus and hospital-acquired methicillin-resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 47:196-203, 2003.
  • Rupp ME, Fey PD. Extended spectrum ß-lactamase (ESBL)-producing Enterobacteriaceae: considerations for diagnosis, prevention, and drug treatment. Drugs. 63:353-365,2003.
  • Fey PD, Rupp ME. Molecular epidemiology in the public health and hospital environments. Clinics in Laboratory Medicine. 23:885-891, 2003.
  • Rupp ME, Craig R. Prevention of Central Venous Catheter Infections. Infections in Medicine. 21:123-127, 2004.
  • Olsen KO, Rudis MI, Rebuck JA, Hara J, Gelmont D, Ramin M, Nelson C, Rupp ME. Effect of once daily dosing vs. multiple daily dosing of tobramycin on enzyme markers of nephrotoxicity. Critical Care Medicine. 32:1678-1682, 2004.
  • Rupp ME, Fitzgerald T, Marion N, Helget V, Puumala S, Anderson JR, Fey PD. Effect of silver-coated urinary catheters: efficacy, cost-effectiveness, and antimicrobial resistance. American Journal of Infection Control. 32:445-450, 2004.
  • Rupp ME, Lisco S, Lipsett P, Perl T, Keating K, Civetta J, Mermel L, Lee D, Dellinger EP, Donahoe M, Giles D, Pfaller M, Maki DG, Sherertz R. Effect of a second-generation chlorhexidine/silver sulfadiazine-impregnated central venous catheter on catheter-associated infections in intensive care unit patients. A randomized, double-blinded, controlled trial. Annals of Internal Medicine. 143:570-580, 2005.
  • Wong ES, Rupp ME, Mermel L, Perl TM, Bradley S, Ramsey KM, Ostrowsky B, Valenti AJ, Jernigan JA, Voss A, Tapper M. Public disclosure of healthcare-associated infections. Infection Control and Hospital Epidemiology. 26:1-3, 2005.
  • Fowler VG, Boucher HW, Corey R, Abrutyn E, Karchmer AW, Rupp ME. Levine DM, Chambers HF, Talley FP, Vigliani G, Cabell CH, Link AS, DeMeyer I, Filler S, Zervos M, Cook P, Parsonnet J, Berstein JM, Price CS, Forrest G, Fatkenheur G, Gareca M, Rehm SJ, Brodt HR, Tice A, Cosgrove SE & S. aureus Endocarditis and Bacteremia Study Group. Daptomycin versus Standard Therapy for Staphylococcus aureus Bacteremia and Endocarditis. N Eng J Med. 355:653-65, 2006.
  • Van Schooneveld T, Rupp ME. Community-Acquired Methicillin-Resistant Staphylococcus aureus: Current Considerations Regarding Epidemiology and Management. Texas Medicine. Summer 2007: 11-14, 2007.
  • Rupp ME, Lee SA, Jourdan DR, Marion ND, Tyner LK, Fey PD, Iwen PC, Anderson JR. Outbreak of bloodstream infections temporally associated with the use of an intravascular positive-displacement needleless valve Clinical Infectious Diseases. 44:1408-14, 2007.
  • Rupp ME, Holley HP, Jr, Lutz P, Dicpinigaitis PV, Woods C, Levine DP, Veney N, Fowler VG, Jr. A phase II, randomized, multicenter, double-blind, placebo-controlled, trial of a polyclonal anti-capsular immunoglobin in the treatment of Staphylococcus aureus bacteremia. Antimicrobial Agents and Chemotherapy. 51:4249-54, 2007.
  • Hermsen ED, Garr M, Reisbig K, Maiefski M, Walker R, Rupp ME. Community-Acquired Methicillin-Resistant Staphylococcus aureus in Nebraska. Cornhusker Family Physician. 53:54-55, 2007.
  • Rupp ME, Fitzgerald T, Puumala S, Anderson JR, Craig R, Iwen PC, Jourdan D, Keuchel J, Marion N, Peterson D, Sholtz L, Smith V. Prospective, Controlled, Cross-Over Trial of Alcohol-Based Hand Gel in Critical Care Units. Infection Control and Hospital Epidemiology 29:8-15, 2008.
  • Erlandson KM, Sun J, Iwen PC, Rupp ME. Impact of More Potent Antibiotics Linezolid and Quinuprisitn/Dalfopristin on Outcome Measures of Patients with Vancomycin-Resistant Enterococcus Bacteremia. Clinical Infectious Diseases. 46:30-6, 2008.
  • Hermsen ED, Shull SS, Puumala S, Rupp ME. Improvement in Prescribing Habits and Economic Outcomes Associated with the Introduction of a Standardized Approach for Surgical Antimicrobial Prophylaxis. Infection Control and Hospital Epidemiology, 29:457-461, 2008.
  • Rupp ME, Iwen PC, Tyner LK, Marion N, Reed E, Anderson JR. Routine Sampling of Air for Fungi Does Not Predict Risk of Invasive Aspergillosis in Immunocompromised Patients. Journal of Hospital Infection. 68:270-271, 2008.
  • Rogers K, Fey PD, Rupp ME. Coagulase-Negative Staphylococcal Infections. Infectious Diseases Clinics of North America. 23:73-98, 2009.
  • Hermsen ED, Smith Shull S, Mitropoulos IF, Puumala SE, Rupp ME. Prospective Evaluation of Clinical and Economic Outcomes Associated with Treatment of Serious Infections due to Gram-positive Cocci. Infectious Diseases in Clinical Practice. 17:17-21, 2009.
  • Kanafani ZA, Arduino JM, Muhlbaie LH, Kaye KS, Allen KB, Carmeli Y, Corey GR, Cosgrove SE, Fraser TG, Harris AD, Karchmer AW, Lautenbach E, Rupp ME, Peterson E, Straus WL, Fowler, VG Jr. Incidence and Pre-operative Risk Factors of Staphylococcus aureus Bacteremia and Wound Infection Following Cardiac Surgery. Infection Control and Hospital Epidemiology, 30:242-248, 2009.
  • Cosgrove SE, Boucher HW, Vigliani GA, Campion M, Fowler VG, Abrutyn E, Corey GR, Rupp ME, Chambers HF, Karchmer AW. Initial Low-Dose Gentamicin for Staphylococcus aureus Bacteremia and Endocarditis is Nephrotoxic. Clinical Infectious Diseases. 48:713-21, 2009.
  • Hermsen ED, Maiefski M, Florescu MC, Qui F, Rupp ME. Comparison of Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault (CG) Equations for Dosing Antimicrobials. (Accepted, Pharmacotherapy, 2009).

Textbooks

  • Biofilms, Infections, and Antimicrobial Therapy. Pace JL, Rupp ME, Finch R (eds). Marcel Dekker CRC Press, New York, 2005.

Chapters

  • Dominguez EA, Rupp ME. Bacterial Pneumonia. In: Rakel RE (Ed), Conn's Current Therapy. W.B. Saunders, Philadelphia, 202-207, 1996.
  • Rupp ME. Infections of Intravascular Catheters and Vascular Devices. In: Crossley K, Archer GL (eds), The Staphylococci in Human Disease. Churchill Livingstone Inc., New York, 379-399, 1997.
  • Rupp ME. Coagulase-Negative Staphylococcal Infection: An Update Regarding Recognition and Management. In: Remington JS, Swartz MN (eds), Current Clinical Topics in Infectious Diseases -Volume 17, Blackwell Scientific Publications, New York, 51-87, 1997.
  • Dominguez EA, Rupp ME, Preheim LC. Fever without neutropenia. In: Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE (Eds), Clinical Oncology, 2nd Edition, Churchill Livingstone, New York, 707-718, 1999.
  • Garvin KL, Luck JV, Rupp ME, Fey PD. Infections in Orthopaedics. In: Buckwalter J, Einhorn T, Simon S. (Eds), Orthopaedic Basic Science, 2nd ed, American Academy of Orthopaedic Surgeons, 239-259, 2000.
  • Rupp ME. Infectious complications of venous access devices. In: Goertzen TC, McCowen TC (Eds), Radiologic Placement and Management of Venous Access Devices, W.B. Saunders, New York.
  • Rupp ME. Infections Associated with Intravascular Catheters. In: Baddour L, Gorbach S (eds). Therapy of Infectious Diseases. Eleseiver Science, Philadelphia. 141-151, 2003.
  • Rupp ME. Nosocomial Bloodstream Infections. In: C Glen Mayhall (ed). Hospital Epidemiology and Infection Control, 3rd edition. Lippincott Williams and Wilkins, Philadelphia, 253-265, 2004.
  • Rupp ME. Control of Gram-Positive Multidrug Resistant Pathogens. In: Lautenbach E, Woeltje K (eds). A Practical Handbook for Hospital Epidemiologists, 2nd Edition. Slack, Inc. Thorofare, NJ. 179-187, 2004.
  • Rupp ME. Mediastinitis. In: Mandell GL, Bennett JE, Dolin R (Eds), Principles and Practice of Infectious Diseases, 6th Edition, Elsevier/Churchill Livingstone, New York, 1070-1078, 2005.
  • Ayi B, Rupp ME. Blastomycosis. In: Rakel RE, Bope ET (eds). Conn’s Current Therapy. 57th Edition. W.B. Saunders Company - Elsevier. New York. 2005, 278-280.
  • Handke LD, Rupp ME. In vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci. In: Pace JL, Rupp ME, Finch R (eds). Biofilms, Infections, and Antimicrobial Therapy. Marcel Dekker CRC Press, New York. 285-299, 2005.
  • Ricardo-Dukelow M, Rupp ME. Mediastinitis. In: Fishman AP, Elias JA, Fishman JA, Grippi MA, Kaiser LR, Senior RM. Pulmonary Diseases and Disorders, 4th Edition, McGraw Hill, New York. 21612172, 2008.
  • Hermsen ED, Rupp ME. Influenza. In: DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM. Pharmacotherapy: A Pathophysiologic Approach. 7th Edition, McGraw-Hill, New York. New York. Chapter 113 p1791-1799, 2008.
  • Rogers KL, Fey PD, Rupp ME. Epidemiology of Infections due to Coagulase-Negative Staphylococci. In: Crossley K, Archer GL, Fowler V (eds), The Staphylococci in Human Disease, 2nd Edition. Churchill Livingstone Inc., New York (Submitted 2007).
  • Rupp ME, Fey PD. Staphylococcus epidermidis and Other Coagulase-negative Staphylococci. In: Mandell GL, Bennett JE, Dolin R (Eds), Principles and Practice of Infectious Diseases, 7th Edition, Elsevier/Churchill Livingstone, New York (Submitted 2008).
  • VanSchooneveld T, Rupp ME. Mediastinitis. In: Mandell GL, Bennett JE, Dolin R (Eds), Principles and Practice of Infectious Diseases, 7th Edition, Elsevier/Churchill Livingstone, New York (Submitted 2008).

Abstracts

  • Cavalieri SJ, Hostetter MK, Rupp ME, Dominguez EA. Synergy studies on and therapy for multiply antibiotic resistant Enterococcus faecium from a recent outbreak. (From the 1994 Annual Meeting of the Infectious Diseases Society of America, Abstract #179), Clin Infect Dis. 19:593, 1994.
  • Dominguez EA, Davis JC, Rupp ME, Goering RV, Winfield B, Iwen PC, Langnas AN. Vancomycin-resistant Enterococcus faecium infections in liver-transplant patients. (From the 1994 Annual Meeting of the Infectious Diseases Society of America, Abstract #115), Clin Infect Dis. 19:583, 1994.
  • Iwen PC, Dominguez EA, Kelly DM, Rupp ME, Linder J. Relative increase in resistance along with a shift in the distribution of Enterococcus species isolated from the blood. (From the 95th General Meeting of the American Society for Microbiology, Abstract L-12, Washington, DC, 1995).
  • Rupp ME. Clinical and Microbiologic Experience in the treatment of vancomycin-resistant Enterococcus faecium with Synercid (Quinopristin/Dalfopristin). (From the 1995 Annual Meeting of the Infectious Diseases Society of America. San Francisco, CA), Abstract #157.
  • Peddicord TE, Olsen KM, Campbell GD Jr, Rupp ME. Anti-pseudomonal effects of lidocaine in bronchial washings and bronchoalveolar lavage. American Journal of Respiratory and Critical Care Medicine, 1996; 153(4):A562.
  • Rupp ME, Hamer KE. Effect of ofloxacin, levofloxacin, d-ofloxacin, vancomycin, and cefazolin on the adherence of Staphylococcus epidermidis to teflon intravascular catheters. (From the 1996 General Meeting of the American Society for Microbiology. Abstract # 2109).
  • Dahm S, Peddicord TE, Rupp ME, Sakurada B, Buchalter SE, Olsen KM. Single dose versus multiple dosing of tobramycin in critical care patients. From the 22nd Annual Midwest Pharmacy Conference, Omaha, NE 1996.
  • Rupp ME, Lewis M. In-vitro activity of bacitracin and bismuth subsalicylate against vancomycin-resistant Enterococcus faecium. Program and Abstracts of the 34th Annual Meeting of the Infectious Diseases Society of America,1996; p118.
  • Peddicord TE, Olsen KM, Campbell GD Jr, Rupp ME. Anti-pseudomonal effects of lidocaine in bronchial washings and bronchoalveolar lavage fluid. Pharmacotherapy. 1996;16(3):A36E.
  • Iwen PC, Rupp ME, Hinrichs SH. Community-acquired invasive aspergillosis in immunocompromised patients. 97th General Meeting of the American Society for Microbiology, Abstract # F-59; p270, 1997.
  • Smith TL, Iwen PC, Olson S, Lewis M, Rupp ME. Environmental contamination with vancomycin-resistant enterococci (VRE) in an outpatient setting. 7th Annual Meeting of the Society for Healthcare Epidemiology of America, Abstract S8. Infection Control and Hospital Epidemiology. 18:15, 1997.
  • Olsen KM, Coyle E, Murante LJ, Sorenson S, Rupp ME. Effect of practice guidelines on antibiotic serum concentration utilization. 32nd Midyear Clinical Meeting of the American Society of Health-System Pharmacists, 1997.
  • Rupp ME, Olsen KM, Bergman KL, Peddicord TE, Fey PD. Comparative study of bactericidal activity and postantibiotic effect of clarithromycin, 14-hydroxyclarithromycin, and azithromycin against clinical isolates of Haemophilus influenzae. Program and Abstracts of the 4th International Conference on the Macrolides, Azalides, Streptogrammins and Ketolides. Abstract 10.05, p 50.
  • Bergman KL, Olsen KM, Peddicord TE, Fey PD, Rupp ME. Comparative study of antimicrobial activity and postantibiotic effect of physiologic levels of clarithromycin, 14-hydroxyclarithromycin, and azithromycin against clinical isolates of Haemophilus influenzae and Streptococcus pneumoniae. Annual Meeting of the American College of Clinical Pharmacy, 1998.
  • Ratanasuwan W, Iwen PC, Hinrichs SH, Rupp ME. Bacteremia due to motile Enterococcal species:clinical features and outcomes. Program and Abstracts from the 98th General Meeting of the American Society for Microbiology, Abstract A-95, p54.
  • Rupp ME, Sisson JH, Peterson D, Radkey F, Winfield B, Olsen KM, Patil KD. Ventilator-associated pneumonia: risk factors and outcome assessment. 8th Annual Meeting of the Society for Healthcare Epidemiology of America. Abstract #S22.
  • Rupp ME, Marion N, Fey PD, Iwen PC, Bolam DL, Overfelt CM, Chapman L. Successful control of an outbreak of vancomycin-resistant enterococci in a neonatal intensive care unit. 8th Annual Meeting of the Society for Healthcare Epidemiology of America. Abstract #118.
  • Rupp ME, Ulphani JS. Efficacy of LY333328 in a rat model of Staphylococcus aureus central venous catheter associated infection. Abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract F-111, p260, 1998.
  • Fey PD, Moland ES, Iwen PC, Hinrichs SH, Rupp ME. Outbreak of extended-spectrum-lactamase-producing Klebsiella pneumoniae in pediatric liver transplant patients. Abstracts of the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract K-127, p538, 1998.
  • Handke LD, Rupp ME, Fey PD. B-lactamase analysis of Klebsiella pneumoniae producing an extended-spectrum B-lactamase isolated from a pediatric intensive care unit. University of Nebraska Medical Center Research Symposium. 1999.
  • Murante LJ, Kwapniowski LA, Deines T, Marion N, Rupp ME. Impact of a vancomycin-utilization educational program at a university teaching hospital. 9th Annual Meeting of the Society for Healthcare Epidemiology of America, Abstract #253, 1999.
  • Rupp ME, Fey PD, Longo MG. Efficacy of LY333328 against vancomycin-resistant enterococci in a rat central venous catheter infection model. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy. Abstract #1004, p 28, 1999.
  • Rebuck JA, Fey PD, Olsen KM, Rupp ME. Characterization of an extended-spectrum beta-lactamase outbreak in a pediatric intensive care unit solid organ transplant population. 39th Interscience Conference on Antimicrobial Agents and Chemotherapy. Abstract #1177, p 614, 1999.
  • Rebuck JA, Fey PD, Bergman KL, Rupp ME, Olsen KM. In vitro activity of beta-lactam antimicrobial agents against TEM-10, TEM-26 and SHV-5 derived extended spectrum beta-lactamases. Annual Meeting of the Infectious Diseases Society of America. Clinical Infectious Diseases. 29:982, 1999.
  • Olsen KM, Rebuck JA, Rupp ME. Arthralgias and myalgias related to Quinupristin/Dalfopristin (Q/D) administration. Annual Meeting of the Infectious Diseases Society of America. Clinical Infectious Diseases. 29:1001, 1999.
  • Medcalf SJ, Chapman L, Craig R, Fey PD, Iwen PC, Marion ND, Overfelt CM, Paxton A, Zack TL, Rupp ME. Successful control of an outbreak due to Serratia marsescens in a neonatal intensive care unit. Program and Abstracts of the 27th Annual Meeting of the Association for Professionals in Infection Control and Epidemiology, 2000, p24.
  • Fey PD, Greenwood SL, Sambol AR, Iwen PC, Rupp ME, Safranek TJ, Hinrichs SH. Prevalence of expanded-spectrum cephalosporin-resistance within human Salmonella isolates from Nebraska. 101st General Meeting of the American Society for Microbiology.
  • Fey PD, Greenwood SL, Sambol AR, Iwen PC, Rupp ME, Safranek TJ, Hinrichs SH. Prevalence of expanded spectrum cephalosporin-resistance within human Salmonella isolates from Nebraska. Abstract C-518. 101st Annual Meeting of the Society for Microbiology. Orlando, FL, 2001.
  • Rupp ME, S Lisco, P Lipsett, T Perl, K Keating, L Mermel, D Lee, EP Dellinger, M Donahoe, D Giles, M Pfaller, R Sherertz. Effect of chlorhexidine/silver sulfadiazine coating on microbial colonization of central venous catheters in a multicenter trial. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, 2001. Abstract K-2047.
  • Fey PD, Boxrud D, Rupp ME, Hinrichs SH, Safranek TJ, Davis CC, Schlievert PM. Comparison of community-acquired and hospital-associated MRSA. 41st Interscience Conference on Antimicrobial Agents and Chemotherapy, 2001. Abstract LB-5.
  • Helget V, Fitzgerald T, Marion N, Fey P, Rupp ME. Effect of a silver alloy coated urinary catheter: Efficacy and cost effectiveness analysis. 12th Annual Meeting of the Society for Healthcare Epidemiology of America, Salt Lake City, April 6-9, 2002. Abstract 272.
  • Medcalf S, Dotzler M, Helget V, Howard T, Iyer K, Korth S, Malashock C, Marion N, Schmer B, Schwedhelm S, Schroeder R, Sudan R, Rupp ME. Program for optimization of delivery of surgical prophylactic antibiotics. 29th Annual Meeting of the Association for Professionals in Infection Control, 2002.
  • Rupp ME, Craig R, Sudan R, Marion N. Surgical site infections associated with robotic surgery. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, 2002. Abstract K-581.
  • Rupp ME. Hemodialysis catheter related bloodstream infections. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, 2002. Abstract 412.
  • Rupp ME, Fitzgerald T, Anderson J, Craig R, Helget V, Iwen P, Jourdan D, Keuchel J, Marion N. Hand Hygiene in an Adult ICU: Impact of an Alcohol-Based Hand Sanitizer. 13th Annual Meeting of the Society for Healthcare Epidemiology of America, Arlington VA, 2003. Abstract #159.
  • Rupp ME, Fitzgerald T, Anderson JR, Craig R, Iwen PC, Jourdan D, Keuchel J, Marion N, Puumala SE, Sholtz L, Smith V. Prospective, Controlled, Cross-Over Trial of an Alcohol-Based hand Sanitizer in an ICU-Setting. 14th Annual Meeting of the Society for Healthcare Epidemiology of America, Philadelphia, PA, April 2004.
  • Rupp ME, Sholtz L, Craig R, Oleynikov D, Marion N. Surgical Site Infections Associated with Robotic Surgery. 15th Annual Meeting of the Society for Healthcare Epidemiology of America, Los Angeles, CA, April, 2005.
  • Rupp ME, Lutz J, Dicpinigaitis P, Woods CW, Levine D, Holley HP Jr. Trial of Staphylococcus aureus capsular polysaccharide immune globin in subjects with S. aureus bacteremia and persistent fever. Abstract LB-6; 43rd Annual Meeting of the Infectious Diseases Society of America. San Francisco, 2005.
  • Fowler V, Cosgrove S, Abrutyn E, Chambers H, Corey R, Denmeyer I, Filler S, Levine D, Link A, Rupp ME, Karchmer AW. Daptomycin vs. standard therapy for Staphylococcus aureus bacteremia and infective endocarditis. 45th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. New Orleans, 2005.
  • Rupp ME, Sholtz LA, Jourdan DR, Marion N, Tyner LK, Fey PD, Iwen PC, Anderson JR. Outbreak of Catheter-Related Bloodstream Infections Temporally Associated with a Positive Displacement Needleless Valve. 16th Annual Meeting of the Society for Healthcare Epidemiology of America, Chicago, 2006. Abstract # 227.
  • Fitzgerald TA, Jourdan DR, Sholtz LA, Murphy EM, Poppert DW, Marion N, Rupp ME. Influenza: Lessons learned form an outbreak, post-exposure prophylaxis, and vaccination campaigns. 33rd Annual Meeting of the Association for Professionals in Infection Control, Tampa, 2006.
  • Cosgrove S, Fowler V, Abrutyn E, Boucher H, Vigliani G, Tally F, Corey R, Levine D, Rupp M, Chambers H, Karchmer A. Synergistic low-dose gentamicin in the treatment of S. aureus bacteremia and endocarditis is nephrotoxic. Abstract 371. 44th Annual Meeting of the Infectious Diseases Society of America. Toronto, Canada. Oct 12-15, 2006.
  • Erlandson KM, Sun J, Iwen P, Rupp ME. Impact of More Potent Antibiotics on Outcome Measures of Patients with Vancomycin-Resistant Enterococcus (VRE) Bacteremia, Abstract 234. 44th Annual Meeting of the Infectious Diseases Society of America. Toronto, Canada. Oct 12-15, 2006.
  • Hermsen E, Mitropoulos I, Smith-Shull S, Puumala S, Rupp ME. Prospective Evaluation of Clinical and Economic Outcomes Associated with Treatment of Serious Infections due to Gram-positive Cocci. Abstract 415. 44th Annual Meeting of the Infectious Diseases Society of America. Toronto, Canada. Oct 12-15, 2006.
  • Hermsen ED, Smith-Shull S, Puumala S, Rupp ME. Comparative Evaluation of Clinical and Economic Outcomes of an Antimicrobial Surgical Prophylaxis (ASP) Order Form. 44th Annual Meeting of the Infectious Diseases Society of America. Abstract 1021. Toronto, Canada. Oct 12-15, 2006.
  • Kanafani ZA, Arduino JM, Muhlbaie LH, Kaye KS, Allen KB, Carmeli Y, Corey GR, Cosgrove SE, Fraser TG, Harris AD, Karchmer AW, Lautenbach E, Rupp ME, Peterson E, Straus WL, Fowler, VG Jr. Incidence and Pre-operative Risk Factors of Staphylococcus aureus Bacteremia and Wound Infection Following Cardiac Surgery. 17th Annual Meeting of the Society for Healthcare Epidemiology of America, Baltimore, 2007.
  • Noel RK, Rupp ME, Hinrichs SH, Erlandson KR, Iwen PC. Incidental Finding of Vancomycin-Resistant Enterococcus (VRE) species in Stool and the Subsequent Development of Systemic VRE Infection. 107th General Meeting of the American Society for Microbiology, Toronto, Ontario, May 21-25, 2007. Abstract L-008.
  • Kanafani Z, Vigliani G, Boucher H, Chambers H, Rupp M, Nasraway S, Rehm S, Campion M, Abrutyn E, Karchmer A, Levine D, Fatkenheuer G, Brodt H, Wolf T, Corey R. Comparison of clinical outcomes in patients with Staphylococcus aureus bacteremia and endocarditis presenting with or without systemic inflammatory response syndrome. 17th European Congress of Clinical Microbiology and Infectious Diseases together with the 25th International Congress of Chemotherapy. Munich, Germany, 2007.
  • Jourdan D, Marion N, Overfelt C, Bolam D, Rupp ME. Sequential approach to a MRSA outbreak in a neonatal ICU. 34th Annual Meeting of the Association for Professionals in Infection Control. San Jose, CA. 2007.
  • Hermsen ED, Shull SS, Klepse DG, Iwen PC, Garrett J, Freifeld AG, Rupp ME. Pharmacoeconomic Analysis of Microbiologic Techniques for Differentiating Gram-Positive Cocci in Clusters (GPCC) Directly from Blood Culture Bottles. 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy. Abstract O-1874. Chicago, Sept 16-20, 2007.
  • Kalil AC, Murthy M, Neto FK, Rupp ME. Are The New Anti-Staphylococcal Drugs Superior to Vancomycin or Oxacillin? Abstract 260. 45th Annual Meeting of the Infectious Diseases Society of America. San Diego, October 4-7, 2007.
  • Hermsen ED, Shull SS, Parizek L, Qui F, Wilderman J, Rupp ME. Antimicrobial Step-Down Conversion on a General Medicine Ward. Abstract 565. 45th Annual Meeting of the Infectious Diseases Society of America, San Diego, October 4-7, 2007.
  • Hermsen ED, Shull SS, Parizek L, Fang Q, Wilderman J, Rupp ME. Outcomes of a Pharmacist-initiated Antimicrobial Step-Down Protocol. 2007 Annual Meeting of the Association for Clinical Pharmacists. Abstract 389. Denver, October 14-17, 2007.
  • Rupp ME, Cavalieri J, Delaney K, Lundgren K, Stammers L, Beach S. Prospective Randomized Controlled Trial Assessing the Clinical Performance of a Transparent Chlorhexidine Gel Pad Intravascular Catheter Dressing. 18th Annual Meeting of the Society for Healthcare Epidemiology of America, Orlando, FL April 5-8, 2008 (Abstract #115).
  • Rupp ME, Fitzgerald T, Sholtz L, Hermsen ED, Iwen PC, Marion N, Jourdan D, Beach S. Multidisciplinary Interventions for the Management and Prevention of Clostridium difficile Associated Diseases at an Academic Medical Center. 2008 Annual Conference of the Association for Professionals in Infection Control.
  • Allen KB, Fowler VG, Muhlbaier L, Kaye KS, Carmeli Y, Cosgrove SE, Fraser TG, Harris AD, Karchmer AW, Rupp ME, Arduino JM. Staphylococcus aureus Infections: Effect on Outcomes in Patients Undergoing Elective Cardiac Surgery. 2008 Annual Meeting of the Southern Thoracic Surgery Society.
  • Kalil AC, Murthy MH, Hermsen E, Neto FK, Sun J, Rupp ME. Linezolid versus Vancomycin or Teicoplanin for Nosocomial Pneumonia: a Meta-Analysis. 48th Annual ICAAC / 46th Annual IDSA Meeting, Washington DC, Oct 25-28, 2008 (Abstract K533)
  • Shull SS, Hermsen ED, Nieman J, Klepser DG, Sholz L, Barnes W, Rupp ME. Assessment of hospital costs attributed to nosocomial vascular catheter-associated bloodstream infection and the potential impact of reimbursement changes. 48th Annual ICAAC / 46th Annual IDSA Meeting, Washington DC, Oct 25-28, 2008. (Abstract K3417).
  • Hermsen ED, Hanson M, Sankaranarayanan J, Stoner J, Florescu M, Rupp ME. Clinical outcomes and nephrotoxicity associated with vancomycin trough concentrations during treatment of deep-seated MRSA infections. Abstract 135. American Association of Clinical Pharmacists Annual Meeting, 2008.
  • Tiwari MM, Hermsen ED, Sholtz L, Rupp ME. Inappropriate use of intravascular catheters: A Prospective Study. 19th Annual Meeting of the Society for Healthcare Epidemiology of America, San Diego, March 19-22, 2009.
  • Tiwari MM, Hermsen ED, Sholtz L, Rupp ME. Prospective study of factors affecting appropriate urinary catheter use. 19th Annual Meeting of the Society for Healthcare Epidemiology of America, San Diego, March 19-22, 2009.
  • Rupp ME, Fitzgerald T, Anderson JR, Eliason R, Jourdan D, Marion N, Sholtz L, Smith V, Thompson S, Tyner K. Hospital-Wide Hand Hygiene Adherence Program and Correlation with Healthcare-Associated Infections. 19th Annual Meeting of the Society for Healthcare Epidemiology of America, San Diego, March 19-22, 2009.

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